Yes, but only using Windows To Go (Rufus method). A standard bootable USB is for installing Windows, not running it live.
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The tool will download Windows 10, verify the files, and write them to your USB. Grab a coffee—this takes 15–30 minutes depending on your internet and USB speed. windows 10 on usb download
The tool will list available drives. Choose your USB—double-check the drive letter so you don’t accidentally wipe the wrong one. Yes, but only using Windows To Go (Rufus method)